Progress in the study of signal transduction pathways related to the pathogenesis of glaucoma

VernacularTitle:青光眼发病机制相关信号转导通路的研究进展
Author: Meng-Han Xu ^{1
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Author Information

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6. an Medical University, Xi'
7. an 710021, Shaanxi Province, China
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10. Department of Ophthalmology, Hanzhong 3201 Hospital, Hanzhong 723200, Shaanxi Province, China
Publication Type:Review
Keywords: glaucoma; signal transduction pathways; retinal ganglion cells; pathogenesis
From: International Eye Science 2021;21(6):1021-1024
CountryChina
Language:Chinese
Abstract: Glaucoma is the leading cause of irreversible vision loss in the world. Drugs and surgery can be used to control intraocular pressure, however, they can't reverse the apoptosis of retinal ganglion cells effectively. With the development of genetics and molecular biology, a large amount of research on the pathogenesis of glaucoma has been conducted. This review discusses the potential role of Rho/ROCK, TGF-β/Smad, PI3K/Akt, Nrf2/Keap1/ARE and BDNF/TrkB signaling pathways in the pathogenesis of glaucoma, and expects to provide new ideas and methods for the treatment of glaucoma.
Full text:202106017.pdf