Application prospects of trigonelline in regulating metabolic disorders after renal transplantation
10.3969/j.issn.1674-7445.2021.03.017
- VernacularTitle:葫芦巴碱调节肾移植术后代谢紊乱的应用前景
- Author:
Zhongda LI
1
;
Dong LIU
;
Xiao WANG
;
Jinyang ZHUANG
Author Information
1. Guangdong Medical University, Zhanjiang 524023, China
- Publication Type:Research Article
- Keywords:
Trigonelline;
Renal transplantation;
Metabolic disorder;
Inflammatory reaction;
Oxidative stress;
Cell apoptosis;
Immunosuppressant;
Glucocorticoid
- From:
Organ Transplantation
2021;12(3):363-
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic disorders, such as glucose and lipid, are likely to occur after renal transplantation, leading to graft dysfunction and reduced long-term survival. Trigonelline is a type of natural alkaloid with various biological activities, which can alleviate the metabolic disorders of glucose, lipid and other types, and relieve inflammatory reaction, oxidative stress and cell apoptosis of the kidney, thereby protecting the renal function. Therefore, trigonelline may be a potential drug to regulate metabolic disorders after renal transplantation. In this article, the role of trigonelline in metabolic disorders of glucose, lipid and other types, and its application prospect in renal transplantation were reviewed, aiming to provide reference for alleviating metabolic disorders after renal transplantation and improving the long-term survival of renal transplant recipients and transplanted kidneys.
