Belatacept: a new weapon in anti-rejection battlefield
10.3969/j.issn.1674-7445.2021.03.005
- VernacularTitle:贝拉西普——抗排斥反应战场上的新武器
- Author:
He SUN
1
;
Yini SUN
;
Ying CHENG
Author Information
1. Department of Organ Transplantation and Hepatobiliary Surgery, the First Hospital of China Medical University, Shenyang 110001, China
- Publication Type:Research Article
- Keywords:
Renal transplantation;
Immunosuppressive regime;
Co-stimulatory blocker;
CD28;
Belatacept;
Rejection;
Cytotoxic T lymphocyte-associated antigen-4;
Posttransplant lymphoproliferative disease
- From:
Organ Transplantation
2021;12(3):280-
- CountryChina
- Language:Chinese
-
Abstract:
As a co-stimulatory blocker against CD28 receptor, belatacept has been approved and applied to the treatment of rejection in organ transplantation in Europe and America. Belatacept has been proven to outperform calcineurin inhibitor (CNI) in improving the long-term survival rate of recipients and grafts, and enhancing graft function. Nevertheless, it might cause a high incidence of rejection. To resolve this issue, transplant workers have attempted to optimize belatacept immunosuppressive regimen and achieved good clinical efficacy. Although belatacept has been proven to exert poor effect on memory T cells, it has potential value in exploring new co-stimulatory molecular targets to optimize immunosuppressive regimes due to its specificity for immune cells and mild adverse effects. In this article, the advent of co-stimulatory blocker, clinical efficacy and application of belatacept, and the causes of belatacept-resistant rejection were reviewed.
