Pathology of antibody-mediated rejection in renal allograft
10.3969/j.issn.1674-7445.2021.03.003
- VernacularTitle:移植肾抗体介导的排斥反应的病理学
- Author:
Hui GUO
1
Author Information
1. Organ Transplantation Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Organ Transplantation of Ministry of Education, Key Laboratory of Organ Transplantation of National Health Commission of China, Key Laboratory of Organ Transplantation of Chinese Academy of Medical Sciences, Wuhan 430030, China
- Publication Type:Research Article
- Keywords:
Antibody-mediated rejection (AMR);
Donor specific antibody (DSA);
Antibody-dependent cell-mediated cytotoxicity (ADCC);
T cell-mediated rejection (TCMR);
Banff classification on allograft pathology (Banff classification);
C4d;
Thrombotic microangiopathy;
Chronic allograft vasculopathy
- From:
Organ Transplantation
2021;12(3):262-
- CountryChina
- Language:Chinese
-
Abstract:
Antibody-mediated rejection (AMR), also known as humoral rejection, is an immune injury caused by rejection involved with multiple humoral immune effectors, such as antibodies and complements, etc. AMR plays a pivotal role in hyperacute, acute and chronic rejection. In this article, the basic definition of AMR, the research progress and major achievements on AMR pathology according to Banff classification on allograft pathology (Banff classification), and main pathological characteristics of AMR in renal allograft were reviewed, aiming to provide reference for accurate diagnosis and timely treatment of AMR, and guarantee the long-term survival of renal graft and recipients.
