Effect of Serotonin on Experimentally Induced Gastric Ulcer in Rats.
- Author:
Myung Hwan CHANG
1
;
Byung Ho CHOI
;
Sa Suk HONG
Author Information
- Publication Type:Original Article
- MeSH: Animals; Female; Gastric Juice/drug effects; Male; Rats; Serotonin/*pharmacology; Stomach Ulcer/*prevention & control
- From:Yonsei Medical Journal 1965;6(1):39-45
- CountryRepublic of Korea
- Language:English
- Abstract: Ulcerative gastric lesions in rats were produced by the procedure of Shay et al. The lesion develops uniformly in the rumen, less often in the antrum, and least frequently in the body of the stomach. Administration of serotonin (8 mg/kg) was effective in preventing the occurrence of gastric lesions and the effect is distinct particularly in the group which had 48 hrs of starvation and 10 hrs of pyloric ligation. Bilateral vagotomy was completely effective and pretreatment of atropine or morphine was moderately effective in preventing the gastric lesions. The acidity of gastric juice was considerably lower, however, the mucin content was higher in the animals treated with serotonin than nontreated control animals. Histobgically, mucus secretion was greater in the animals that were given serotonin. In summary, it is concluded that serotonin is effective in preventing ulceration in the stomach by its action of increasing mucin secretion and inhibitory gastric acid secretion.
