Research advances in anti-hepatitis B virus therapy targeting covalently closed circular DNA
DOI:10.3969/j.issn.1001-5256.2021.05.044
- VernacularTitle:靶向共价闭合环状DNA抗HBV治疗的研究进展
- Author:
Yiying WANG
1
;
Xichen LIU
;
Rongli PIAO
;
Junjie QIN
Author Information
1. Department of Hepatology, The First Hospital of Jilin University, Changchun 130000, China
- Publication Type:Research Article
- Keywords:
Covalently Closed Circular DNA;
Hepatitis B Virus;
Gene Editing
- From:
Journal of Clinical Hepatology
2021;37(5):1189-1192.
- CountryChina
- Language:Chinese
-
Abstract:
The incurable chronic infection caused by hepatitis B virus (HBV) is the major health burden worldwide. Covalently closed circular DNA (cccDNA) exists in the nucleus of infected cells as a stable minichromosome, and when a new therapy realizes inactivation or eliminates persistent cccDNA in infected hepatocytes, the natural process of chronic infection and long-term antiviral therapy will no longer exist. This article introduces the methods targeting cccDNA, such as gene editing and epigenetic modification, so as to achieve the complete cure of HBV infection.
