Research progress of neutrophil extracellular traps and related targeted drugs for the treatment of inflammatory diseases
10.16438/j.0513-4870.2020-1673
- VernacularTitle:中性粒细胞胞外诱捕网及其相关靶向药物在治疗炎症性疾病中的研究进展
- Author:
Yan DING
;
Jiao QU
;
Yang SUN
- Publication Type:Research Article
- Keywords:
neutrophil extracellular trap;
inflammatory disease;
inflammation;
targeting therapy
- From:
Acta Pharmaceutica Sinica
2021;56(3):669-678
- CountryChina
- Language:Chinese
-
Abstract:
The inflammatory response is an essential role of innate immune cells such as neutrophils, which plays an important role in the occurrence and development of inflammatory diseases. Neutrophil extracellular traps (NETs) are responsible for killing microorganisms and inducing the inflammatory response. We review the function of NETs in inflammatory diseases based on research publications since 2016. In addition, the ability of drugs that target NETs to ameliorate inflammation-related diseases is summarized. This review suggests a new strategy of targeting NETs for the treatment of inflammation-related diseases.
