The combined therapeutic effects of 5-aminolevulinic acid cubic liquid crystal and light needles for basal cell cancer
10.16438/j.0513-4870.2020-1657
- VernacularTitle:5-氨基酮戊酸立方液晶联合光针治疗基底细胞癌的研究
- Author:
Pei-pei MA
1
,
2
;
Qi LI
1
,
2
;
Ge OU
1
;
Yuan-yuan ZHANG
1
,
2
;
Qian LI
1
,
2
;
Li-na DU
1
,
2
Author Information
1. Beijing Institute of Radiation Medicine, Beijing 100850, China
2. Department of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
- Publication Type:Research Article
- Keywords:
5-aminolevulinic acid;
cubic liquid crystal;
light needle;
basal cellcarcinoma;
photodynamics
- From:
Acta Pharmaceutica Sinica
2021;56(3):865-871
- CountryChina
- Language:Chinese
-
Abstract:
The article was to study the effect of local photodynamics therapy combined with carbon dioxide lattice laser - "light needles" for the treatment of basal cell carcinoma (BCC). 5-Aminolevulinic acid (5-ALA) cubic liquid crystal using glyceryl monostearate (GMO) as the substrate was prepared. The cytotoxicity of 5-ALA cubic liquid crystal combined with light needles in vitro were evaluated. The pharmacodynamics study of 5-ALA cubic liquid crystal combined with light needles of high or low energy for BCC was carried out based on the pathological changes, tumor volume, vascular endothelial growth factor (VEGF) expression and the recurrence rate, which has been approved by the Ethics Committee of Beijing Institute of Radiation Medicine. The cubic liquid crystal was isotropic with the lattice of PN3M. The cytotoxicity of 5-ALA cubic liquid crystal combined with light needles was much higher than that of 5-ALA or light needles alone. Compared with light needles or photodynamic therapy alone, 5-ALA cubic liquid crystal combined with light needles of high energy could prevent the BCC metastasis and of low energy could inhibit BCC growth. It demonstrated the obvious therapeutical effects for BCC. 5-ALA cubic liquid crystal combined with light needles can effectively treat BCC, which provides a new choice for clinical BCC treatment.
