The mechanism of NLRP3 inflammasome affecting vascular aging and the development of related drugs
10.16438/j.0513-4870.2020-1513
- VernacularTitle:NLRP3炎性小体影响血管衰老的机制及其相关药物的研发
- Author:
Xiao-man JI
;
Ming XU
- Publication Type:Research Article
- Keywords:
NLRP3 inflammasome;
heart aging;
vascular aging;
cardiovascular and cerebrovascular disease;
anti-aging;
senolytics
- From:
Acta Pharmaceutica Sinica
2021;56(3):696-702
- CountryChina
- Language:Chinese
-
Abstract:
Nucleotide binding oligomerization domain (NOD)-like receptor protein 3, NLRP3) inflammasomes regulate the secretion of caspase-1, interleukin-18 (IL-18), IL-1β, and other cytokines, and participates in aging. In recent years, it has been found that NLRP3 inflammasomes are abnormally activated in aging heart and vessels, and inhibition of NLRP3 inflammasomes can alleviate heart aging and vascular aging. This review summarizes the research of NLRP3 inflammasome in heart and vascular aging, and the related drugs to promote the discovery of the mechanism of NLRP3 inflammasome in heart and vascular aging and the development of related drugs.
