Biphasic dissolution test and its application in the evaluation of poorly soluble drug preparations
10.16438/j.0513-4870.2020-1491
- VernacularTitle:两相溶出系统及其在难溶性药物制剂评价中的应用
- Author:
Qing LIU
;
Ya-qi ZHANG
;
Wen-xi WANG
- Publication Type:Research Article
- Keywords:
biphasic dissolution;
italic>in vitro-in vivo correlation;
issolution and partition;
poorly water soluble drug
- From:
Acta Pharmaceutica Sinica
2021;56(3):743-750
- CountryChina
- Language:Chinese
-
Abstract:
Biphasic dissolution test, consisting of immiscible aqueous and organic phase, is an in vitro dissolution method that simultaneously measures the dissolution and partition of drugs. Due to the advantages of simulating in vivo absorption and overcoming the influence of surfactants on dissolution, it has been widely used to evaluate the poorly soluble drugs in vitro dissolution. Based on the relevant research in this field in recent years, this review summarizes the history, dissolution device, theoretical model and application of the biphasic dissolution test. Finally, the prospects in the development of biphasic dissolution test are also outlined.
