Advances in drug research targeting the Wnt signaling pathway in colorectal cancer
10.16438/j.0513-4870.2020-1422
- VernacularTitle:靶向结直肠癌Wnt信号通路的药物研究进展
- Author:
Yu-fei WANG
;
Hai-jing ZHANG
;
Lian-qiu WU
- Publication Type:Research Article
- Keywords:
colorectal cancer;
Wnt signaling pathway;
targeted drug;
small molecule inhibitor;
natural compound
- From:
Acta Pharmaceutica Sinica
2021;56(3):689-695
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer is a common malignant tumor in the gastrointestinal tract, with the characteristics of high morbidity and mortality. Studies have shown that the occurrence and development of colorectal cancer is closely related to the abnormal activation of Wnt signaling pathway. Abnormal expression of β-catenin in Wnt pathway is found both in the cytoplasm and nucleus of tumor cells. Different drugs can target the Wnt signaling pathway and its upstream and downstream related factors to inhibit or suppress the development of colorectal cancer. We review the components of Wnt signaling pathway, and the correlation between Wnt signaling pathway and colorectal cancer. Then, we summarize the current status of drug research targeting the Wnt signaling pathway in colorectal cancer. Finally, the challenges and prospects of these methods and drugs were briefly summarized.
