Review of novel compounds that act on the AT2 receptor
10.16438/j.0513-4870.2020-1389
- VernacularTitle:作用于AT2受体化合物的研究进展
- Author:
Yan-chun ZHANG
1
,
2
;
Zu-zhi ZHANG
1
;
Jin-yi XU
3
;
Dan-hui WANG
1
;
Mei-yue XU
1
Author Information
1. College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
2. Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei 230012, China
3. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
- Publication Type:Research Article
- Keywords:
angiotensin receptor type 2 receptor;
agonist;
antagonist;
selectivity;
structure and activity relationship
- From:
Acta Pharmaceutica Sinica
2021;56(3):711-722
- CountryChina
- Language:Chinese
-
Abstract:
Selective activation or inhibition of the angiotensin II type 2 (AT2) receptor can cause vasodilation, decrease cell proliferation, promote neurite outgrowth and block neuronal excitability. The AT2 receptor can be used as a potential drug target for the treatment of cardiovascular diseases, fibrosis, inflammation, neuronal diseases and tumors. Research and development of new drugs that selectively act on the AT2 receptor and the mechanism of intracellular signal transduction involving the AT2 receptor is a challenging but worthy endeavor. We review research progress on the AT2 receptor and compounds that act on the AT2 receptor, along with structure-activity relationship analysis, to provide reference and guidance for further research in this field.
