Current status of treatment and drug discovery for neuropathic pain
10.16438/j.0513-4870.2020-1131
- VernacularTitle:神经病理性疼痛的治疗和药物发现现状
- Author:
Jia-nan SONG
1
,
2
;
Hai-bo YU
3
;
Yu-mei LIU
1
Author Information
1. Department of Neurobiology, Harbin Medical University, Harbin 150086, China
2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
3. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
neuropathic pain;
pharmacological treatment;
ion channel;
G-protein coupled receptor;
rug discovery
- From:
Acta Pharmaceutica Sinica
2021;56(3):679-688
- CountryChina
- Language:Chinese
-
Abstract:
Neuropathic pain (NP) is a medical problem that has been bothering human beings and seriously affects people's quality of life. Although great progress has been made in the study of NP in recent years, there are still many patients who are ineffective to the existing treatments. At present, drug therapy is still the main method to relieve pain, however, adverse drug reactions has hindered the curative effects of drugs. It is extremely urgent to find new drug targets and reduce the adverse effects of existing drugs. This review will mainly describe the current situation and pathogenesis of neuropathic pain, effectiveness and limitations of existing drugs for treating neuropathic pain, and the current status of drug discovery.
