Research progress on dental pulp stem cells in the repair of peripheral nerve injury
10.12016/j.issn.2096-1456.2021.07.012
- Author:
XU Xiaohang
1
;
XU Wanqiu
1
;
YAO Lihong
1
;
WANG Xiumei
1
Author Information
1. Department of Oral Medicine, the Second Affiliated Hospital of Harbin Medical University
- Publication Type:Review
- Keywords:
dental pulp stem cells;
Schwann cells;
stem cells from human exfoliated deciduous teeth;
peripheral nerve injury;
Wallerian degeneration;
axon regeneration;
tissue engineering;
nerve conduits
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2021;29(7):500-504
- CountryChina
- Language:Chinese
-
Abstract:
Peripheral nerve injury (PNI) is a common disease in the oral cavity that can easily lead to loss of function and abnormal appearance. The application of dental pulp stem cells (DPSCs) combined with tissue engineering in the repair of PNI is a research hotspot. DPSCs have the advantages of abundant sources, simple extraction, low immunogenicity and a high proliferation rate in vitro. They can differentiate into Schwann cells (SCs). SCs can induce autophagy and secrete key neurotrophic factors, such as nerve growth factor, brain-derived neurotrophic factor, ciliary neurotrophic factor and glial cell-derived neurotrophic factor. SCs are beneficial for the repair of nerve injury. DPSCs in different periods have differences in immune regulation, anti-inflammatory effects, expression of neural markers, angiogenesis and so on, which provide more diversified choices for nerve repair. At present, the introduction of tissue engineering provides a more controllable and improved microenvironment for DPSCs, which is conducive to the application and development of DPSCs in regenerative medicine and tissue engineering. However, there are still many problems to be solved, such as the selection of stem cells, functional link recovery, uncontrollable direction of axon regeneration, regulation of the peripheral nervous system and mechanism of repair.
- Full text:牙髓干细胞在周围神经损伤修复中的研究进展.pdf
