Cutaneous involvement of multiple myeloma
- Author:
Norhafizah Mohtarrudin
1
Author Information
1. Departments of Pathology Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor
- Collective Name:Ikmal Hisyam Bakrin; Dawn Ambrose; Lim Jo Lyn; Nur Syahida Ayuni Mukhtar
- Publication Type:Case Reports
- Keywords:
Cutaneous multiple myeloma;
plasmacytoma;
erythematous nodules;
plasma cells
- From:The Malaysian Journal of Pathology
2021;43(1):75-79
- CountryMalaysia
- Language:English
-
Abstract:
Cutaneous multiple myeloma (MM) is a rare disease. It can be primary or secondary in origin.
The secondary type is further classified into specific and nonspecific types. The specific type is
uncommon and is known as a secondary cutaneous plasmacytoma. We report a case of secondary
cutaneous plasmacytoma in a 58-year-old man who had a history of plasma cell tumour of the lung
and multiple myeloma. He achieved complete remission after the completion of chemotherapy
and autologous stem cell transplant (ASCT). However, five months later, he developed multiple
erythematous nodules on the whole body. Skin biopsy revealed diffuse neoplastic cells infiltrate in
the reticular dermis with sparing of the upper papillary dermis and epidermis. The neoplastic cells
were monotonous and homogenous with variable degrees of cytological atypia. Occasional cells
showed distinctive plasma cell features. Plasma cell lineage was confirmed with CD138. The cells
were immunoreactive to Kappa. Ki-67 was greater than 90%. They were non-immunoreactive to
CD45, CD3, CD20, CD79 alpha and CK AE1/AE3. The findings were consistent with secondary
cutaneous plasmacytoma. Our case illustrates that MM may present with nonspecific dermatological
manifestations. As specific cutaneous involvement of MM is very uncommon; a high degree of
clinical suspicion, detailed medical history and histopathological examination are required to arrive
at an early diagnosis.
- Full text:5.2021my01112.pdf
