Metastatic leiomyosarcoma of the thyroid: A rare entity
- Author:
Nur Asyilla Che Jalil
1
Author Information
1. Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia
- Collective Name: Poobalan Rama Chandran; Ahmad Hadif Zaidin Samsudin; Maya Mazuwin Yahya; Wan Faiziah Wan Abdul Rahman
- Publication Type:Case Reports
- Keywords:
Metastatic thyroid cancer;
leiomyosarcoma
- From:The Malaysian Journal of Pathology
2021;43(1):69-73
- CountryMalaysia
- Language:English
-
Abstract:
Cancer metastasis to the thyroid gland from non-thyroid sites is a rare presentation in clinical
practice. The most frequent primary cancers that metastasise to the thyroid are renal cell carcinoma,
followed by colorectal, lung and breast. We report a case of a 64-year-old Malay lady who presented
with anterior neck swelling 4 years after an initial diagnosis of uterine leiomyosarcoma. She had
undergone a hysterectomy procedure four years ago. Fine needle aspiration cytology of the thyroid
mass suggested undifferentiated thyroid carcinoma. After multi-disciplinary discussion, the patient
underwent thyroidectomy and the final histopathological diagnosis was metastatic leiomyosarcoma
of the thyroid. The diagnosis was aided by an immunohistochemistry panel of positive myogenic
markers, negative epithelial markers as well as the previous medical history of uterine leiomyosarcoma.
Metastatic leiomyosarcoma of the thyroid may mimic primary undifferentiated (anaplastic) thyroid
carcinoma (UTC) with a sarcomatoid pattern, medullary thyroid carcinoma (MTC) with spindle
cells morphology and spindle cell tumour with thymus-like differentiation (SETTLE). Hence, a
multidisciplinary approach must be practised by pathologists, surgeons and radiologists to consider
metastatic lesions of the thyroid gland, especially when a previous history of cancer exists or is
suspected.
- Full text:5.2021my01111.pdf
