A national audit of estimated glomerular filtration rate and proteinuria and the MACB CKD Task Force recommendations
- Author:
Pavai Sthaneshwar
1
Author Information
1. Department of Pathology, Faculty of Medicine, University Malaya
- Collective Name: Leslie Charles Lai; Raja Elina Raja Azzidin; Baizurah Mohd. Hussain; Siti Sharina Anas; Sivasangkari Supremaniam; Low Yoke Lee; Nafisah Mohamad Noor; Harmiza Bte Harun
- Publication Type:Journal Article
- Keywords:
CKD;
eGFR;
Urine albumin
- From:The Malaysian Journal of Pathology
2021;43(1):41-48
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: The Malaysian Association of Clinical Biochemists (MACB) established a Task Force
for Chronic Kidney Disease. A survey was undertaken by the Task Force on the reporting of estimated
glomerular filtration rate (eGFR) and urine albumin by hospital laboratories in Malaysia in both the
government and private sectors. Materials and Methods: An e-mail invitation to participate in an
online survey was sent to hospital laboratories in Malaysia (n=140). Questions regarding methods
for measuring creatinine, equations for calculating eGFR, eGFR reporting, the terminology used
in reporting urine albumin, types of samples and the cut-off values used for normal albuminuria.
Results: A total of 42/140 (30%) laboratories answered the questionnaire. The prevalent method used
for serum creatinine measurement was the Jaffé method (88.1%) traceable to isotope-dilution mass
spectrometry. eGFR was reported along with serum creatinine by 61.9% of laboratories while 33.3%
of laboratories report eGFR on request. The formula used for eGFR reporting was mainly MDRD
(64.3%) and results were reported as exact numbers even when the eGFR was >60 ml/min/1.73m2
.
The term microalbumin is still used by 83.3% of laboratories. There is a large heterogeneity among
the labs regarding the type of sample recommended for measuring urine albumin, reference interval
and reporting units. Conclusion: It is evident that the laboratory assessment of chronic kidney disease
in Malaysia is not standardised. It is essential to provide a national framework for standardised
reporting of eGFR and urine albumin. Recommendations developed by the MACB CKD Task Force,
if adopted by all laboratories, will lead to a reduction in this variability.
- Full text:5.2021my01107.pdf
