High sensitivity C-reactive protein (hsCRP): Its relationship with metabolic syndrome and Framingham Risk Score
- Author:
Siti Yazmin Zahari Sham
1
Author Information
1. Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor
- Collective Name:Evana Hanif; Subashini C. Thambiah; Intan Nureslyna Samsudin; Sabariah Mohd Noor; Malina Osman; Hafizah Abdullah; Khadhijah Mustaffa
- Publication Type:Journal Article
- Keywords:
High sensitivity C-reactive protein (hsCRP);
Cardiovascular disease (CVD);
Framingham Risk Score (FRS);
Metabolic Syndrome (MetS)
- From:The Malaysian Journal of Pathology
2021;43(1):33-40
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Cardiovascular disease (CVD) remains the leading cause of death in Malaysia.
Identification of asymptomatic at-risk individuals is often achieved by means of a risk prediction
algorithm. Traditional CVD risk factors and their associated algorithms are, however, limited by
residual CVD risk. High sensitivity C-reactive protein (hsCRP) has emerged as a novel CVD
risk factor. This study aimed to evaluate hsCRP as an adjunct CVD risk marker among the adult
Malaysian population by determining its correlation with the Framingham Risk Score (FRS).
Comparison analyses were done according to sociodemographic, clinical and laboratory factors
and between subjects with and without Metabolic Syndrome (MetS). Method: This cross-sectional
study involved eighty-three (n=83) adults attending a health screening program at Universiti Putra
Malaysia (UPM). Demographic data, anthropometric measurements and blood samples for fasting
blood glucose (FBG), fasting lipid profile (FSL), glycated haemoglobin (HbA1c) and hsCRP were
taken. Respondents were grouped according toFRSand the Joint Interim Statementinto 10-year CVD
risk categories (low, intermediate and high) and MetS, respectively. Results: hsCRP was significantly
increased in patients with high body mass index (BMI) (p=0.001), at-risk waist circumference (WC)
(p=0.001) and MetS (p=0.009). Spearman’s correlation coefficient showed a significant positive
correlation between hsCRP level and total FRS score (r=0.26, p<0.05) and HDL-C score (r=0.22,
p<0.05). Conclusion: The significant difference of hsCRP levels across obesity levels and MetS
with its modest correlation with FRS scores supported the adjunctive role of hsCRP in CVD risk
prediction, most likely capturing the inflammatory pathological aspect and thus partly accounting
for the residual CVD risk.
- Full text:5.2021my01106.pdf
