Comparison of platelet rich fibrin and acellular dermal matrix in repairing rabbits′ oral mucosal defects
10.12016/j.issn.2096-1456.2021.07.002
- Author:
WANG Chengyu
1
;
FAN Yawei
2
;
WANG Jue
2
Author Information
1. Shanxi Medical University Stomatology Hospital
2. First Hospital of Shanxi Medical University
- Publication Type:Journal Article
- Keywords:
acellular dermal matrix;
platelet rich fibrin;
autologous connective tissue transplantation;
oral mucosa defect;
dental implant;
wound healing rate;
inflammation level;
epithelial thickness;
animal experiment
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2021;29(7):442-448
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects of platelet-rich fibrin (PRF) and acellular dermal matrix (ADM) on the repair of oral mucosal defects and to provide the basis for soft tissue growth in oral implant operations.
Methods:Thirty-six healthy male Japanese big ear rabbits were randomly divided into the PRF group, ADM group, Autograft group (autologous connective tissue transplantation group) and Control group (blank control group); each group contained nine rabbits. Between the midline and the hard palate maxillary incisors, in an 8-mm location preparation and a 10-mm standard mucosa defect, the ADM group, PRF and Autograft group were implanted with ADM, autologous PRF and autologous cornification mucosa, respectively, whereas the control group had wound gauze compression processing at 7, 14, and 21 days to determine the wound healing rate in the area selected by HE staining. The inflammatory grade and average epithelial thickness were observed, and the results were statistically analyzed.
Results :Compared with the control group, the PRF, ADM and Autograft groups had significantly advanced wound healing (P < 0.05). The wound healing degree in the PRF group was similar to that of the ADM group at all time points (P > 0.05). The wound healing degree in the PRF and ADM groups was lower than that of the Autograft group at each time point (P < 0.05). HE staining results showed that compared with the control group, the levels of inflammation in the PRF group, ADM group and Autograft group were reduced, and the difference was statistically significant (P < 0.05). Nevertheless, there was no significant difference between the PRF, ADM and Autograft groups (P > 0.05). The epithelial thickness in the ADM group was similar to that in the Autograft group (P > 0.05). The epithelial thickness in the ADM group was higher than that in the PRF group at 7 d and 14 d (P < 0.05), but there was no significant difference at 21 d (P > 0.05).
Conclusion :PRF and ADM have similar healing effects in repairing oral mucosa defects, and they can be used as soft tissue augmentation materials instead of connective tissue transplantation.
- Full text:富血小板纤维蛋白与脱细胞真皮基质修复兔口腔黏膜缺损效果比较.pdf
