Interaction effects between childhood emotional overeating and polygenic influences on pubertal timing and tempo
10.16835/j.cnki.1000-9817.2021.04.005
- VernacularTitle:童年期情绪性多食与多基因遗传风险对青春期发育的交互效应研究
- Author:
LIU Wanxu, JIANG Weikang, ZHAO Li, XIONG Jingyuan, SU Puyu, WAN Yuhui, FANG Jiao, CHENG Guo, SUN Ying
1
Author Information
1. School of Public Health, Anhui Medical University, Hefei(230032), China
- Publication Type:期刊文章
- Keywords:
Food habits;
Genes;
Heredity;
Puberty;
Regression analysis;
Child
- From:
Chinese Journal of School Health
2021;42(4):497-500
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the interaction effects and possible sex differences in childhood emotional overeating and polygenic influences on adolescent pubertal timing and tempo.
Methods:In March 2016 (T0), all participants were recruited from grades 1 to 3 from two primary school of Bengbu, Anhui Province using cluster sampling, and follow up surveys were conducted once per year (T1, T2, T3). Emotional overeating was assessed at T1 and pubertal development was assessed annually (breast Tanner stage in girls and testicular volume in boys). The nonlinear growth model was used to estimate pubertal timing and tempo. Polygenic risk scores were calculated based on 17 SNPs for early pubertal timing. Hierarchical linear regression was performed to examine the interaction effects between childhood emotional overeating and polygenic risk scores on pubertal timing and tempo.
Results:The complete data of 896 children were analyzed, including 373 boys (41.60%) and 523 girls (58.40%). A total of 203 (22.7%) children reported emotional overeating behavior at T1. After adjusting for several variables including early life adversity, delivery mode, and birthweight, only emotional overeating was associated with accelerated pubertal tempo among girls with a high genetic risk (B=0.19, 95%CI=0.07~0.32， P<0.01), although there was no association with pubertal timing (B=0.14, 95%CI=-0.12~0.41，P=0.28). In girls with a low genetic risk and boys, no evidence was found to support interaction effects between childhood emotional overeating and polygenic influences on pubertal timing and tempo (P＞0.05).
Conclusion:Emotional overeating was associated with a faster pubertal tempo in girls who had a high genetic risk of early pubertal development.
