25-hydroxyvitamin D, bone source alkaline phosphatase and ultrasound bone density combined in detection of rickets in infants
10.19428/j.cnki.sjpm.2020.19666
- VernacularTitle:血清25-羟维生素D、骨源性碱性磷酸酶、超声骨密度联合检测在婴幼儿佝偻病检出中的应用
- Author:
Chun-min BO
1
;
Ya-ping HOU
;
Jing ZHANG
Author Information
1. Shanghai Changning District Maternal and Child Health Hospital, Shanghai 200051, China
- Publication Type:Research Article
- Keywords:
infants and young children;
rickets;
ultrasonic bone density;
25-hydroxyvitamin D
- From:
Shanghai Journal of Preventive Medicine
2020;32(7):592-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the application of serum 25-hydroxyvitamin D (25-OH-D), bone source alkaline phosphatase (BAP) and ultrasonic bone mineral density (BMD) in the detection of infantile rickets aged 3-12 months. Methods Six to 12 months old rickets infants and healthy ones were randomly selected from March to December 2018 in a hospital in Changning, who were divided into two groups as observation or control group (160 infants in each).Two groups were respectively tested with serum 25-OH-D, BAP activity and ultrasonic bone density, so as to explore the diagnostic efficacy of the three combined tests for infant rickets. Results The serum 25-OH-D level and the BMD in the observation group were significantly lower than that in the control group (P < 0.05), and the abnormal detection rate of BAP in the control group was significantly lower than that in the observation group (P < 0.05).There was no statistical significance (P>0.05) between the three detection methods, but the sensitivity and accuracy of the three detection methods combined were significantly better than that of any single detection method (P < 0.05). Conclusion The combined detection with serum 25-OH-D level, BAP activity and ultrasonic BMD can significantly improve the detection efficiency of rickets in infants aged 6-12 months, which is valuable and worthy of clinical application.
