Progress in research on the determination of entrapment efficiency of liposomes
10.11665/j.issn.1000-5048.20210214
- VernacularTitle:载药脂质体包封率测定方法的研究进展
- Author:
ZHANG Yi
1
;
HANG TaiMinjun
;
SONG Min
Author Information
1. 中国药科大学药物分析系
- Publication Type:Journal Article
- Keywords:
liposome entrapment efficiency;
centrifugation;
centrifugation ultrafiltration;
Sephadex gel column;
microcolumn centrifugation;
dialysis and reverse dialysis
- From:
Journal of China Pharmaceutical University
2021;52(2):245-252
- CountryChina
- Language:Chinese
-
Abstract:
Liposome, a new dosage form, has become important in improving in vivo behavior of drugs or realizing targeted drug delivery. Study and control of its critical processes and quality attributes are the main challenges in the current research on liposomes. The degree of encapsulation can determine drug''s effect in vivo directly, thus entrapment efficiency (EE) has turned into one of the critical quality attributes of liposome.In this paper some methods commonly used for the determination of EE and their characteristics are summarized and analyzed, and the main factors to be considered for the determination are discussed.
