Research and reflections on the nitric oxide-donating cardio-cerebrovascular drugs
10.11665/j.issn.1000-5048.20210201
- VernacularTitle:一氧化氮供体型心脑血管药物研究的实践与思考
- Author:
WU Jianbing
1
;
HUANG Zhangjian
;
ZHANG Yihua
Author Information
1. 中国药科大学新药研究中心
- Publication Type:Journal Article
- Keywords:
nitric oxide;
NO-donating cardio-cerebrovascular drugs;
physiological and pathological functions;
effector molecule;
signal transduction species
- From:
Journal of China Pharmaceutical University
2021;52(2):129-143
- CountryChina
- Language:Chinese
-
Abstract:
Nitric oxide (NO) as a signal transduction species and/or effector molecule plays an extremely important role in the cardiovascular, nervous, and immune systems. Insufficient production or abnormal signal transduction of NO is closely associated with onset and progression of many diseases. Studies on direct or indirect regulation of NO levels in vivo and related metabolic pathways have become a hot spot in biomedical and pharmaceutical fields. This review briefly introduces the generation of NO in vivo and its physiological and pathological functions in cardio-cerebrovascular system, with focus on the authors'' research on NO-donating cardio-cerebrovascular and related drugs, aiming to provide some reference for future development of these drugs.
