The association between maternal serum Vitamin D levels and Gestational Diabetes Mellitus among Filipino patients

Carmen Carina Cabrera; Oliver Allan Dampil; Albert Macaire Ong-lopez

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The association between maternal serum Vitamin D levels and Gestational Diabetes Mellitus among Filipino patients

Author: Carmen Carina Cabrera ¹ ; Oliver Allan Dampil ¹ ; Albert Macaire Ong-Lopez ²
Author Information

1. Section of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, St. Lukes Medical Center, Quezon City, Philippines
2. Department of Medicine, St. Lukes Medical Center, Quezon City, Philippines
Publication Type:Journal Article
Keywords: gestational diabetes mellitus; gestational diabetes
MeSH: vitamin D deficiency; Diabetes, Gestational
From: Journal of the ASEAN Federation of Endocrine Societies 2020;35(2):169-175
CountryPhilippines
Language:English
Abstract: Objectives. To determine the association between low maternal serum vitamin D and gestational diabetes mellitus (GDM) among Filipino women in St. Luke’s Medical Center, Quezon City. Methodology. A cross-sectional study involving pregnant women at outpatient clinics in a tertiary hospital in the Philippines. Simultaneous testing for fasting blood sugar, 75g oral glucose tolerance test and serum vitamin D was done. Participants were classified as GDM versus non-GDM, and normal versus low serum vitamin D. Univariate and multivariate statistics were done to determine relationship between vitamin D and GDM. Results. Of 211 included women, 198 (93.8%) had low vitamin D levels, and 56 (26.5%) had GDM. Vitamin D was significantly higher in the GDM group (21.0±8.1 vs 18.8±5.3 ng/mL, p=0.0189). The proportion of women with low vitamin D levels was significantly higher among those without GDM (96.1% vs 87.5%, OR=0.28, p=0.029]. After adjusting for age, parity, history of GDM and pre-pregnancy BMI, no significant association was observed (adjusted OR=0.66, p=0.522). No correlation was seen between vitamin D and FBS (r=0.28, p=0.095), 1-hour post-75 g OGTT (r=0.26, p=0.643), and 2-hour post-75 g OGTT (r=0.28, p=0.113). Conclusion. There was an association found between maternal serum vitamin D level and GDM in the univariate analysis, but none was evident after adjusting for possible confounders. The unanticipated high prevalence of low vitamin D levels among pregnant Filipinos needs to be verified in future studies.
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