Clinical characteristics, residual beta-cell function and pancreatic auto-antibodies in Thai people with long-standing type 1 diabetes mellitus
10.1007/s13340-019-00393-x
- Author:
Yotsapon Thewjitcharoen
1
;
Sirinate Krittiyawong
1
;
Somboon Vongterapak
1
;
Soontaree Nakasatien
1
;
Suphab Aroonparkmongkol
2
;
Thep Himathongkam
1
;
Ishant Khurana
3
;
Assam El-Osta
3
Author Information
1. Diabetes and Thyroid Center, Theptarin Hospital, Bangkok, Thailand
2. Division of Pediatric Endocrinology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
3. Epigenetics in Human Health and Disease Laboratory, Department of Diabetes, Central Clinical School, Faculty of Medicine Nursing and Health Sciences, Monash University, Melbourne, Australia
- Publication Type:Journal Article
- Keywords:
type 1 diabetes mellitus;
long-standing;
residual beta-cell function;
pancreatic autoantibodies;
Thai people
- MeSH:
Diabetes Mellitus, Type 1;
Autoantibodies;
Thailand;
Pancreas;
Insulin-Secreting Cells;
Disease Progression
- From:
Journal of the ASEAN Federation of Endocrine Societies
2020;35(2):158-162
- CountryPhilippines
- Language:English
-
Abstract:
Objectives. To describe the characteristics of long-standing T1DM in Thai patients and assess residual beta-cell function with status of pancreatic autoantibodies.
Methodology. This is a cross-sectional study of Thai subjects with T1DM and disease duration ≥ 25 years seen at the Theptarin Hospital. Random plasma C-peptide and pancreatic auto-antibodies (Anti-GAD, Anti-IA2, and Anti-ZnT8) were measured. Patients who developed complications were compared with those who remained free of complications.
Results. A total of 20 patients (males 65%, mean age 49.4±12.0 years, BMI 22.5±3.1 kg/m2, A1C 7.9±1.6%) with diabetes duration of 31.9±5.1 years were studied. Half of the participants remained free from any diabetic complications while the proportions reporting retinopathy, nephropathy, and neuropathy were 40%, 30%, and 15%, respectively. HDL cholesterol was significantly higher and triglyceride concentration significantly lower in patients who were free from diabetic nephropathy but not in those who were free from other complications. The prevalence rates of anti-GAD, anti- IA2, and anti-ZnT8 were 65%, 20%, and 10%, respectively. None of the patients who tested negative for both anti-GAD and anti-IA2 was positive for anti-ZnT8. Residual beta-cell function based on detectable random plasma C-peptide (≥ 0.1 ng/mL) and MMTT was found in only 3 patients (15%). There was no relationship between residual beta-cell function and protective effects of diabetic complications.
Conclusion. Endogenous insulin secretion persists in some patients with long-standing T1DM and half of longstanding T1DM in Thai patients showed no diabetic complications. HDL cholesterol was significantly higher and triglyceride concentration significantly lower in patients who were free from diabetic nephropathy
- Full text:845-Article Text-10549-2-10-20201129.pdf
