Clinical analysis of 379 patients of coronavirus disease 2019 (COVID-19) in Chengdu
- VernacularTitle:成都 379 例新型冠状病毒肺炎的临床分析
- Author:
Zhu CHEN
1
;
Yi MAO
1
;
Ting CHEN
1
;
Zhaoxia HU
1
;
Lijuan LAN
1
;
Dafeng LIU
1
;
Jiafu WEI
2
;
Jiachuan WANG
3
Author Information
1. Emergency Ward, Public Health Clinical Center of Chengdu, Chengdu, 610066, P.R.China
2. Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, P.R.China
3. Department of Infectious Diseases, The 2nd Affiliated Hospital of Chengdu Medical College, Nuclear Industry 416 Hospital, Chengdu, 610051, P.R.China
- Publication Type:Journal Article
- Keywords:
Coronavirus disease 2019 (COVID-19);
elderly;
clinical features;
treatment;
prognosis
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2021;28(04):388-395
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical features and prognosis of coronavirus disease 2019 (COVID-19) patients. Methods A total of 379 confirmed COVID-19 patients admitted to Public Health Clinical Center of Chengdu from January 16 to November 30, 2020 were divided into two groups including an elderly group (42 patients, ≥60 years) and a non-elderly group (337 patients, <60 years) by age. The epidemiology, clinical features, laboratory tests, treatment and prognosis of the two groups were compared. Results Among the 379 patients, 286 (75.5%) were males and 93 (24.5%) were females, aged from 2 months to 87 years, with an average age of 41.2 years. The average age of the elderly group was 69.5 years, and 61.9% of them were females. They were imported from Wuhan or local secondary patients (73.8%), mainly common or critical type (88.1%). While, the average age of the non-elderly group was 37.8 years, and males were more common (80.1%). There were mostly from foreign input (75.7%), mainly mild or ordinary type (95.0%). A total of 179 patients (47.2%) had one or more underlying diseases. Hypertension (15 patients, 35.7%) and diabetes (11 patients, 26.2%) were more common in the elderly group, while non-alcoholic steatohepatitis (132 patients, 39.2%) was more frequent in the non-elderly group. The most common clinical manifestations were fever (138 patients, 36.4%) and cough (129 patients, 34.0%). Fever, cough, dyspnea, and fatigue were more common in the elderly group than those in the non-elderly group (P<0.05). Compared with the non-elderly group, the elderly group had lower total lymphocyte count, CD4+ and CD8+ T-cell count, higher level of myocardial injury or inflammation markers (P<0.05). Abnormal echocardiography in 139 patients (36.7%) was mainly caused by decreased left ventricular diastolic function (22.7%) and heart valve regurgitation (14.0%), and the rate in the elderly group was significantly higher than that in the non-elderly group (85.7% vs. 30.6%, P<0.05). After treatment, 3 patients in the elderly group died, and the others were cured and discharged. The hospitalization duration of the elderly group was longer than that of the non-elderly group (22.1 d vs. 18.8 d, P=0.033). Conclusions Elderly COVID-19 patients are mainly imported from Wuhan or secondary to the local population, mainly common or critical type, often associated with basic diseases such as hypertension or diabetes. While, non-elderly COVID-19 patients are mainly imported from abroad, mainly mild or common type, often associated with non-alcoholic steatohepatitis. After treatment, most of the patients have a good prognosis.
