Expression of oestrogen-α receptor in papillary thyroid carcinoma and its association with metastasis
- Author:
Siti Atiqah Ab Halim
1
Author Information
1. Department of Pathology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia,
- Collective Name:Siti Atiqah Ab Halim; Suk Kam Lee; Muaatamarulain Mustangin; Muhammad Fakhri Mohd Saleh; Shamsul Azhar Shah; Nurismah Md Isa
- Publication Type:Journal Article
- Keywords:
Papillary thyroid carcinoma;
immunohistochemistry;
disease progression;
prognosis
- From:The Malaysian Journal of Pathology
2020;42(3):415-422
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Papillary thyroid carcinoma (PTC) is the ninth most common malignancy among
women. Although the disease prognosis is good, less favourable outcomes are predicted in
those with higher disease stages and nodal metastasis. Oestrogen- α (ER-α) expression has been
associated with aggressive presentation and greater disease progression and has been proposed as
a predictor for lymph node metastases. The objective of this study was to evaluate the association
between ER expression and clinicopathological features i.e. lymph node metastasis, tumour size,
extrathyroidal extension, histological variants of PTC , age groups , ethnic and gender. Methods: We
studied ER-α expression in 84 cases of PTC obtained within an eight-year period (2011-2018) by
immunohistochemical technique (IHC). Associations between ER-α expression and clinicopathological
features were evaluated using Fisher’s exact test. The statistical significance was set at p < 0.05.
Results: ER-α was expressed in 13.1% of all the PTC cases examined (n=11/84). There were no
associations observed between ER-α expression and lymph node metastasis (p=1.000), tumour size
(p=0.970), extrathyroidal extension (p=0.677), variants of PTC (p=1.000), age groups (p=0.188),
gender (p=0.725) or race (p=0.920). Conclusion: There was no evidence in this study to support
the application of ER-α as prediction marker for lymph node metastasis or disease aggressiveness
in PTC. Given that the scope of this study was limited to the protein expression of ER- α, we
also propose the inclusion of molecular analysis of ESR1 gene expression, as well as inclusion
of detailed clinical and radiological findings in future research investigating the role of ER-α in
prognostication of PTC.
- Full text:5.2020my01089.pdf
