Expression of Bex1 and NF-kBp65 in tongue squamous cell carcinoma and its significance
10.12016/j.issn.2096-1456.2021.06.004
- Author:
WANG Qianqian
1
;
DING Dandan
1
;
DING Xiang
2
;
HAN Rui
1
;
HAN Yingying
1
;
ZHOU Meiyun
1
;
XU Jincheng
1
Author Information
1. Department of Stomatology, the First Affiliated Hospital of Bengbu Medical College
2. Department of Stomatology, the Second Affiliated Hospital of Bengbu Medical College
- Publication Type:Journal Article
- Keywords:
tongue neoplasms;
squamous cell carcinoma;
invasion;
metastasis;
TNM stage;
Bex1;
NF-kBp65;
immunohistochemistry;
prognosis
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2021;29(6):383-387
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the expression of brain expressed X-linked gene 1(Bex1) and nuclear factor-kBp65 (NF-kBp65) in tongue squamous cell carcinoma, and its significance.
Methods: Immunohistochemistry was used to detect the expression of Bex1 and NF-kBp65 in 60 tongue squamous cell carcinoma (TSCC) tissues and adjacent normal tissues, and the relationships between Bex1, NF-kBp65 and the clinicopathological features and prognosis of patients were analyzed.
Results :The positive expression rate of Bex1 in TSCC was 48.3% (29/60), which was significantly lower than that in adjacent normal tissues 88.3% (53/60) (x2=22.18, P < 0.01). The positive rate of Bex1 was negatively correlated with TNM stage, and the difference was statistically significant (P < 0.05). The positive rate of 63.3% (38/60) in TSCC was significantly higher than 20% (12/60) in adjacent normal tissues (x2=23.18, P < 0.01), the positive rate of NF-kBp65 was positively correlated with TNM stage, and the difference was statistically significant (P < 0.05). According to the Pearson correlation analysis results, the expression of Bex1 and NF-kBp65 in TSCC tissues was negatively correlated (r=-0.302, P=0.019). Kaplan-Meier survival curves showed that the survival rate of Bex1 positive patients was significantly higher than that of Bex1 negative patients.
Conclusion :In TSCC tissues, the low positive expression rate of Bex1 and the high positive expression rate of NF-kBp65 may promote tumor invasion and metastasis, and the negative expression of Bex1 may be related to the poor prognosis of patients.
- Full text:Bex1和NF-kBp65在舌鳞状细胞癌组织中的表达及意义.pdf
