A link between long non-coding RNA (lncRNA) and thalassaemia: A review
- Author:
Afshan Sumera
1
Author Information
1. School of Medicine, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, Malaysia
- Collective Name:Ammu K Radhakrishnan; Abdul Aziz Baba; Elizabeth George
- Publication Type:Review
- Keywords:
Thalassaemia;
long non-coding RNA (lncRNA);
erythropoiesis
- From:The Malaysian Journal of Pathology
2020;42(3):323-332
- CountryMalaysia
- Language:English
-
Abstract:
The long non-coding RNAs (lncRNAs) are the most prevalent and functionally diverse member
of the non-coding RNA (ncRNA). The lncRNA has previously been considered to be a form of
transcriptional “noise” but recent studies have found that the lncRNA to be associated with various
disease conditions. It has also been found to play important roles in various physiological processes
such as haemopoiesis, where lncRNA is reported to act as a fine-tuner of this very important process.
To date, the effects of dysregulated lncRNA in thalassaemia has not been fully explored. This review
article focuses on the possible roles of dysregulated lncRNAs in the pathogenesis of thalassaemia.
- Full text:5.2020my01079.pdf
