Mechanism of action of suppressor of cytokine signaling 1 in the development and progression of liver inflammatory diseases
DOI:10.3969/j.issn.1001-5256.2021.04.055
- VernacularTitle:细胞因子信号转导抑制因子1在肝脏炎症性疾病发生发展中的作用机制
- Author:
Xia WU
1
;
Xiaoning ZHU
;
Yurong ZHANG
;
Yue YIN
;
Mengyun PENG
;
Ding ZHENG
;
Jing WANG
Author Information
1. Department of Hepatobiliary Diseases, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China
- Publication Type:Research Article
- Keywords:
Liver Diseases;
Suppressor of Cytokine Signaling 1 Protein;
Gene Expression Regulation
- From:
Journal of Clinical Hepatology
2021;37(4):973-976
- CountryChina
- Language:Chinese
-
Abstract:
The development of liver inflammatory diseases is associated with autoimmunity and inflammatory response. As a negative feedback regulator of cell signal, suppressor of cytokine signaling 1 (SOCS1) plays a key role in the development and progression of inflammatory diseases. This article mainly introduces the mechanism of action of SOCS1 in autoimmunity and inflammatory response and briefly describes its role in the development and progression of liver inflammatory diseases such as viral hepatitis and nonalcoholic steatohepatitis. The analysis shows that the abnormal expression of SOCS1 in inflammatory response is associated with the regulation of cytokine receptor, Toll-like receptor, and hormone receptor signal, which leads to the development of inflammatory diseases. Therefore, SOCS1 has potential prospects as an auxiliary means for the diagnosis and treatment of liver inflammatory diseases.
