NLRP6 as a Negative Regulator of Innate Immunity.
- Author:
Zahid MANZOOR
1
;
Young Sang KOH
Author Information
- Publication Type:Letter
- Keywords: Nod-like receptor pyrin domain-containing protein 6; Inflammasome; Listeria monocytogenes
- MeSH: Animals; B-Lymphocytes; Cell Transformation, Neoplastic; Colitis; Cytoskeletal Proteins; Immunity, Innate; Inflammasomes; Interferon Type I; Listeria monocytogenes; Mice
- From:Journal of Bacteriology and Virology 2013;43(1):64-66
- CountryRepublic of Korea
- Language:English
- Abstract: Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) play important role in immune responses by regulating nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB), type I interferon and inflammasomes. Nod-like receptor pyrin domain-containing protein 6 (NLRP6) is vital for protection of mice from colitis and colorectal tumorigenesis. However, the role of NLRP6 in microbial infection remains unclear. NLRP6 was recently reported as negative regulator of inflammatory signaling and demonstrated that how it hinders clearance of bacterial pathogens.
