Paving the way to improve clinical management of acute-on-chronic liver failure using international criteria
DOI:10.3969/j.issn.1001-5256.2021.04.001
- VernacularTitle:慢加急性肝衰竭的国际标准与临床管理优化
- Author:
Zhujun CAO
1
;
Chenxi ZHANG
;
Qing XIE
Author Information
1. Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
- Publication Type:Research Article
- Keywords:
Acute-On-Chronic Liver Failure;
Liver Cirrhosis;
Diagnosis;
Therapeutics;
Clinical Governance
- From:
Journal of Clinical Hepatology
2021;37(4):745-751
- CountryChina
- Language:Chinese
-
Abstract:
Acute-on-chronic liver failure (ACLF) is a clinical disease significantly different from acute liver failure and acute decompensation of simple liver cirrhosis, and it may have acute progression to liver failure and failure of other organs. ACLF has a high short-term mortality rate and has become a disease burden worldwide. In recent years, several international associations for the study of the liver have proposed different diagnostic criteria for ACLF and published their respective consensus or review on the diagnosis and treatment of ACLF, and there are still great differences in the comprehension of chronic liver diseases, acute injury, and organ failure. At present, there are still limited data for the key links of ACLF management in China, such as liver transplantation, intensive care unit, and palliative care, and in the context of no consensus on the diagnosis of ACLF around the world, it is necessary to further strengthen the application of existing international criteria and evidence and the accumulation of evidence-based data in China.
