Effect of antibiotics on treatment efficacy of immune checkpoint inhibitors in nonsmall cell lung cancer: A Meta-analysis
DOI: 10.3872/j.issn.1007-385x.2021.02.010
- VernacularTitle:抗生素对免疫检查点抑制剂治疗非小细胞肺癌疗效影响的 Meta 分析
- Author:
HUO Gengwei
1
,
2
,
3
,
4
,
5
,
6
,
7
,
8
;
SONG Ying2b
9
,
10
,
11
;
CHEN Weidong2a
8
,
9
;
CHONG Daoqun2a,
8
,
9
;
JIA Shasha2a
8
,
9
;
CHEN Peng1
1
,
2
,
3
,
4
,
5
,
6
,
7
Author Information
1. 1. Department of Thoracic Oncology, Tianjin Medical University Cancer Institute and Hospital
2. National Clinical Research Center for Cancer
3. Key Laboratory of Cancer Prevention and Therapy, Tianjin
4. Tianjin'
5. s Clinical Research Center for Cancer
6. Tianjin Lung Cancer Center
7. Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, Tianjin 300060, China
8. a. Department of Oncology
9. Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, Tianjin 300060, China
10. b. Department ofPharmacy, Jining No.1 People&rsquo
11. s Hospital, Jining 272000, Shandong, China
- Publication Type:Clinical Trial
- Keywords:
non-small lung cancer(NSCLC);
immune checkpoint inhibitor;
antibiotics;
programmed death 1(PD-1);
programmed death
- From:
Chinese Journal of Cancer Biotherapy
2021;28(2):165-170
- CountryChina
- Language:Chinese
-
Abstract:
[Abstract] Objective: To investigate the effects of antibiotics on the treatment efficacy of immune checkpoint inhibitors in NSCLC
(non-small cell lung cancer) with Meta-analysis. Methods: Literatures regarding the effects of antibiotics on the treatment efficacy of
immune checkpoint inhibitors in NSCLC were searched in Pubmed, Cochrane Library, Embase, EBSCO, Chinese Biomedical Literature
Database(CBM) and Chinese Journal Full-text Database(CNKI). RevMan 5.3 software was used in this Meta-analysis. Results:
Fourteen articles involving 2 505 NSCLC patients were included in this study. Meta-analysis showed that the application of antibiotics
could significantly shorten the PFS (HR=1.14, 95%CI =1.04-1.26, P=0.005) and OS (HR=1.30, 95%CI =1.14-1.47, P<0.0001) of
NSCLC patients treated with immune checkpoint inhibitors. Conclusion: Application of antibiotics before, concurrently or after
immune checkpoint inhibitors in the treatment of NSCLC may significantly shorten PFS and OS, resulting in adverse effect on treatment
efficacy.
- Full text:zgzlswzlzz-2021-2-165.pdf
