Expressions of melanoma lineage antigens and nuclear antigen Ki-67 and their correlations with prognosis in melanoma patients

Bai Xue; LI Caili; Mao Lili; Wei Xiaoting; QI Zhonghui; Sheng Xinan; Cui Chuanliang; Chi Zhihong; Lian Bin; Wang Xuan; Yan Xieqiao; Tang Bixia; Zhou Li; LI Siming; Duan Rong; XU Huayan; Guo Jun; SI Lu

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Expressions of melanoma lineage antigens and nuclear antigen Ki-67 and their correlations with prognosis in melanoma patients

VernacularTitle:黑色素瘤患者种系抗原及核抗原Ki-67 的表达水平及其与预后的关系
Author: BAI Xue ^{1
,

2} ; LI Caili ^{1
,

2} ; MAO Lili ^{1
,

2} ; WEI Xiaoting ^{1
,

2} ; QI Zhonghui ^{1
,

2} ; SHENG Xinan ^{1
,

2} ; CUI Chuanliang ^{1
,

2} ; CHI Zhihong ^{1
,

2} ; LIAN Bin ^{1
,

2} ; WANG Xuan ^{1
,

2} ; YAN Xieqiao ^{1
,

2} ; TANG Bixia ^{1
,

2} ; ZHOU Li ^{1
,

2} ; LI Siming ^{1
,

2} ; DUAN Rong ^{1
,

2} ; XU Huayan ^{1
,

2} ; GUO Jun ^{1
,

2} ; SI Lu ^{1
,

2}
Author Information

1. Department of Melanoma, Peking University Cancer Hospital &
2. Beijing Institute for Cancer Research, Beijing 100142, China
Publication Type:Clinical Trial
Keywords: melanoma; lineage antigen; Ki-67; prognosis; survival
From: Chinese Journal of Cancer Biotherapy 2021;28(2):157-164
CountryChina
Language:Chinese
Abstract: [Abstract] Objective: To explore the expression patterns of melanoma lineage antigens and nuclear antigen Ki-67 and their correlations with survival in melanoma patients. Methods: A retrospective analysis was conducted to analyze the pathological data of melanoma patients treated at the Department of Melanoma, Peking University Cancer Hospital from February 2008 to August 2020, mainly including the expression patterns of melanoma lineage antigens (S-100, HMB-45, Melan-A) and Ki-67, demographics, clinical features and survival. The correlation between expression patterns of melanoma lineage antigens, Ki-67 and melanoma-specific survival (MSS) was analyzed. Results: In total, 603 patients were included in this study. The median follow-up time was 47.4 months. The positive rates of S-100, HMB, and Melan-A were 92.8%, 92.1% and 90.0%, respectively. The percentages of patients with melanoma lineage antigen scores (S-100, HMB-45 and Melan-A was scored each, as 1 when positive and 0 when negative) of 0, 1, 2, and 3 were 0.5%, 5.0%, 15.6%, and 78.8%, respectively. The percentages of patients with Ki-67 scores of 0, 1, 2, and 3 were 43.0%, 36.3%, 16.3%, and 4.5%, respectively. Ki-67 was highly expressed in mucosal and progressive melanomas. In a multivariate analysis, Ki-67 expression was an independent prognostic factor for poorer MSS (HR=1.506, 95%CI: 1.248-1.818, P<0.001) as the incidence of MSS event increased by 50% per 25% increase in Ki-67 expression, whereas there was no statistical correlation between melanoma lineage antigen expression and MSS (HR=0.991, 95%CI: 0.759-1.293, P=0.94). Conclusion: High expressions melanoma lineage antigens are ubiquitous in melanoma tissues, and Ki-67 is an independent prognostic factor for MSS.
Full text:zgzlswzlzz-2021-2-157.pdf