T lymphocyte homing: a critical factor of adoptive cell therapy for solid tumors
DOI: 10.3872/j.issn.1007-385x.2021.02.001
- VernacularTitle:T 淋巴细胞归巢：实体肿瘤过继性细胞治疗的关键因素
- Author:
TAN Siyi
1
;
MENG Fanyan
1
;
LIU Baorui
1
Author Information
1. The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing
- Publication Type:Journal Article
- Keywords:
solid tumor;
T-lymphocyte homing;
chemokines;
adoptive cell therapy
- From:
Chinese Journal of Cancer Biotherapy
2021;28(2):103-108
- CountryChina
- Language:Chinese
-
Abstract:
[Abstract] In recent years, tumor immunotherapy has developed rapidly, among which T-cell-based adoptive cell therapy has achieved
certain clinical effect and become one of the most potential immunotherapeutics. T cell infiltration mainly includes rolling, adhesion,
extravasation and chemotaxis etc. However, there are physical barriers, chemokine mismatch, vascular abnormalities,
immunosuppressive microenvironment and other factors that limit the efficacy of adoptive cell therapy. The homing ability of T cells
can be further improved by optimizing the chemokine receptor on the cell surface, inserting targeted peptide, improving the way of administration, and adopting combined treatment of radiotherapy, immune checkpoint blocker, tumor vaccine and bispecific antibody,
etc. This review mainly summarizes the process of T cell infiltration, the influencing factors of T cell targeting tumor site and the
relevant treatment strategies, as well as gives a prospection for future research.
- Full text:zgzlswzlzz-2021-2-103.pdf
