Efficacy and Safety of Xianling Gubao Capsule Combined with Glucosamine in the Treatment of Knee Osteoar- thritis：A Meta-analysis
- VernacularTitle:仙灵骨葆胶囊联合氨基葡萄糖治疗膝骨关节炎有效性和安全性的Meta分析
- Author:
Zihui ZHENG
1
;
Tian ZHANG
1
;
Qiong LI
1
;
Wenying LI
1
;
Hua YUAN
1
;
Baige ZHANG
1
;
Lin MA
1
;
Pengfei JIN
1
Author Information
1. Dept. of Pharmacy，Beijing Hospital/National Center of Gerontology/Institute of Geriatric Medicine，Chinese Academy of Medical Sciences/ Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application （Beijing Hospital ），Beijing 100730，China
- Publication Type:Journal Article
- Keywords:
Xianling gubao capsule;
Glucosamine;
Knee
- From:
China Pharmacy
2021;32(7):870-875
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To systematically evaluate the efficacy and safety of Xianling gubao capsule combined with glucosamine in the treatment of knee osteoarthritis （KOA），and to provide evidence-based reference for clinical treatment of KOA. METHODS：Retrieved from Cochrane library ，PubMed，Embase，CNKI，Wanfang database ，CBM and VIP during the inception to Nov. 2020，randomized controlled trials （RCTs）about glucosamine （control group ）combined with Xianling gubao capsule （trial group）in the treatment of KOA were collected. After data extraction ，Cochrane 5.1.0 system evaluator manual was used to evaluate the quality of the included clinical studies met inclusion criteria ，and Rev Man 5.4 software was used for Meta-analysis. RESULTS ： A total of 11 RCTs with 970 patients were included in this study. Results of Meta-analysis showed that cure rate [OR ＝2.41，95％CI （1.48，3.93），P＜0.001]，marked effective rate [OR ＝1.95，95％CI（1.49，2.56），P＜0.001]，total effective rate [OR ＝4.00，95％CI （2.57，6.24），P＜0.001]，visual analogue scale （VAS）score [MD ＝－2.34，95％CI（－2.51，－2.17），P＜0.001]，knee function score [MD ＝31.32，95％CI（27.89，34.75），P＜0.001]，Japanese Orthopaedic Association （JOA）low back pain score [MD ＝ 12.22，95％CI（9.68，14.76），P＜0.001] and pain relief time [MD ＝－1.55，95％CI（－1.84，－1.25），P＜0.001] of trial group were all significantly better than those of control group. The incidence of ADR in trial group was significantly lower than control group [OR ＝0.04，95％CI（0.02，0.12），P＜0.001]. CONCLUSIONS ：Xianing gubao capsule combined with glucosamine in the treatment of KOA is significantly better in cure rate ，marked effective rate ，total effective rate ，VAS，score，knee function score，JOA low back pain score and pain relief time ，and could significantly reduce the incidence of ADR.
