Encapsulation of Ginseng inside Poly(lactic-co-glycolic acid)/ Polyaniline Microcaspsules

Alex Zhen Kai Lo; Siti Khadijah Lukman; Syafiqah Saidin

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Encapsulation of Ginseng inside Poly(lactic-co-glycolic acid)/ Polyaniline Microcaspsules

Author: Alex Zhen Kai Lo ¹ ; Siti Khadijah Lukman ¹ ; Syafiqah Saidin ^{1
,

2}
Author Information

1. School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor Malaysia&
2. IJN-UTM Cardiovascular Engineering Centre, Institute of Human Centered Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia
Publication Type:Journal Article
Keywords: Encapsulation, Ginseng, Microcapsule, Polyaniline, Poly(lactic-co-glycolic acid)
From:Malaysian Journal of Medicine and Health Sciences 2020;16(Supp 8, Aug):1-5
CountryMalaysia
Language:English
Abstract: Introduction: : Ginseng is a type of traditional medicine that has been used for thousand years to treat various diseases and has been proven effective in treating cardiovascular diseases. Incorporation of polyaniline (PANI) which is a type of conductive polymer together with ginseng into poly(lactic-co-glycolic acid) (PLGA) microcapsules is necessary for the treatment of cardiovascular diseases as the polymer will control drug release and the electroconductivity of PANI is beneficial on myocardium cells. Methods: Therefore, this project involved the encapsulation of ginseng inside PLGA/PANI microcapsules. The encapsulation of ginseng inside the microcapsules was verified through the identification of chemical composition of ginseng, PLGA and PANI using attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR). Results: The results of scanning electron microscope (SEM) showed the formation of microspheres where the microcapsule size was decreased from 3.14±1.87 μm to 1.98±1.30 μm as the concentration of PANI increased. The distribution of microcapsules size was more homogeneous in the high concentration of PANI as been determined through the histogram analysis. In addition, the fluorescence analysis demonstrated the efficiency of ginseng encapsulation inside PLGA/PANI microcapsules through the appearance of stained ginseng inside the microcapsules. Conclusion: As a conclusion, the ginseng was successfully encapsulated within PLGA/PANI microcapsules that will be beneficial in drug delivery application, specifically in the cardiovascular area.
Full text:11.2020my0797.pdf