Effect of nicotinamide mononucleotide on mortality of mice with endotoxic shock
10.12206/j.issn.1006-0111.202102006
- VernacularTitle:烟酰胺单核苷酸对内毒素休克小鼠死亡率的影响
- Author:
Dongsheng WANG
1
;
Sili ZHENG
1
;
Minghe CHENG
1
;
Chaoyu MIAO
1
Author Information
1. Department of Pharmacology, Naval Medical University, Shanghai 200433, China.
- Keywords:
nicotinamide mononucleotide;
lipopolysaccharide;
endotoxic shock;
mortality
- From:
Journal of Pharmaceutical Practice
2021;39(2):134-137
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of nicotinamide mononucleotide (NMN) on the mortality of the lipopoly-saccharide (LPS)-induced endotoxic shock mouse model. Methods 10-week-old C57BL/6J male mice were randomly divided into groups, and were injected intraperitoneally (i.p.) with LPS (10 mg/kg) to induce endotoxic shock models. NMN was i.p. injected in three ways: (1) 0.5 h after modeling, doses of 10, 30, 100 and 300 mg/kg; (2) 0.5 h before modeling, doses of 30, 100, 300 and 600 mg/kg; or (3) 0.5 and 12 h after modeling, dose of 300 mg/kg each time. The death times of each group were recorded, and the survival curves were drawn. Results Compared with the solvent control group, NMN at different doses given 0.5 h after or before modeling didn’t improve the survival rate or delay the death time of endotoxic shock mice; But when given at 0.5 and 12 h 300 mg/kg after modeling, NMN accelerated the death of mice and increased the mortality of mice. NMN products by two manufacturers showed similar effects. Conclusion NMN has no therapeutic effect on LPS-induced endotoxic shock, and repeated administration of NMN after endotoxic shock will increase the mortality.
