Determination of lanthanum in whole blood by microwave digestion-inductively coupled plasma optical emission spectrometry
10.12206/j.issn.1006-0111.202012019
- VernacularTitle:微波消解-电感耦合等离子体原子发射光谱法测定全血中的镧
- Author:
Jingru ZHANG
1
;
Junjie HUA
1
;
Ling HAN
1
;
Min ZHU
1
;
Ying LU
1
Author Information
1. Department of Pharmaceutics, School of Pharmacy, Naval Medical University, Shanghai 200433, China.
- Keywords:
lanthanum;
microwave digestion;
sunscreen and jellyfish sting protective lotion;
inductive plasma optical emission spectrometry;
transdermal
- From:
Journal of Pharmaceutical Practice
2021;39(2):118-120
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the transdermal safety of lanthanum (La) in sunscreen and jellyfish sting protective lotion, establish a microwave digestion-inductively coupled plasma opticalemission spectroscopy (ICP-OES) method for determination of lanthanum (La) in rat’s whole blood. Methods The whole blood samples were digested by microwave and analyzed by inductively coupled plasma emission spectrometer (ICP-OES). Using 333.749 nm as the analysis line, the content of La in rat whole blood was determined. Results The correlation linearity of the standard curve of this method was good (r>0.9994), the detection limit of the method was 0.0025 μg/ml, the limit of quantification was 0.0077 μg/ml, the precision was less than 3%, and the recovery rate was between 94.9% and 102.0%. Conclusion The ICP-OES method based on microwave digestion is stable and reliable, and can provide an important basis for the study of the transdermal safety of lanthanum.
