A study of pathological characteristics and BRAF V600E status in Langerhans cell histiocytosis of Vietnamese children
- Author:
Thu Dang Anh PHAN
1
;
Bao Gia PHUNG
;
Tu Thanh DUONG
;
Vu Anh HOANG
;
Dat Quoc NGO
;
Nguyen Dinh The TRINH
;
Tung Thanh TRAN
Author Information
- Publication Type:Original Article
- From:Journal of Pathology and Translational Medicine 2021;55(2):112-117
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:Langerhans cell histiocytosis (LCH) is more common in children than adults and involves many organs. In children, the BRAF V600E mutation is associated with recurrent and high-risk LCH.
Methods:We collected paraffin blocks of 94 pediatric LCH patients to detect BRAF V600E mutation by sequencing. The relationship between BRAF V600E status and clinicopathological parameters were also critically analyzed.
Results:BRAF V600E mutation exon 15 was detected in 45 cases (47.9%). Multiple systems LCH showed a significantly higher BRAF V600E mutation rate than a single system (p=.001). No statistical significance was evident for other clinical characteristics such as age, sex, location, risk organs involvement, and CD1a expression.
Conclusions:In Vietnamese LCH children, the proportion of BRAF V600E mutational status was relatively high and related to multiple systems.
