Sarcopenia as a Predictor of Prognosis in Early Stage Ovarian Cancer
- Author:
Su Hyun CHAE
1
;
Chulmin LEE
;
Sang-Hee YOON
;
Seung-Hyuk SHIM
;
Sun Joo LEE
;
Soo-Nyung KIM
;
Sochung CHUNG
;
Ji Young LEE
Author Information
- Publication Type:Original Article
- From:Journal of Korean Medical Science 2021;36(1):e2-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:To identify sarcopenia as a predictive prognostic factor of ovarian cancer in terms of survival outcome in patients with early-stage ovarian cancer.
Methods:Data of Konkuk University Medical Center from March 2002 to December 2017 were reviewed retrospectively. Eighty-two patients who underwent surgery due to early-stage (International Federation of Gynecology and Obstetrics stage I/II) ovarian cancer and had computed tomography (CT) images taken at the initial diagnosis were included. The initial CT scan images were analyzed with SliceOmatic software (TomoVision). A sarcopenia cutoff value was defined as a skeletal muscle index of ≤ 38.7 cm2 /m2 . Overall survival (OS) times were compared according to the existence of sarcopenia, and subgroup analyses were performed.
Results:A Kaplan-Meier analysis showed a significant survival disadvantage for patients with early-stage ovarian cancer when they had sarcopenia (P < 0.001; log-rank test). Sarcopenia remained a significant prognostic factor for OS in early-stage ovarian cancer, in a Cox proportional hazards model regression analysis (HR, 21.9; 95% CI, 2.0–199.9; P = 0.006).
Conclusion:This study demonstrated that sarcopenia was predictive of OS in patients with early-stage ovarian cancer. Further prospective studies with a larger number of patients are warranted to determine the extent to which sarcopenia can be used as a prognostic factor in ovarian cancer.
