Diagnostic Performance of Serum Asialo α1 -Acid Glycoprotein Levels to Predict Liver Cirrhosis
- Author:
Dae Hyun LIM
1
;
Mimi KIM
;
Dae Won JUN
;
Min Jung KWAK
;
Jai Hoon YOON
;
Kang Nyeong LEE
;
Hang Lak LEE
;
Oh Young LEE
;
Byung Chul YOON
;
Ho Soon CHOI
;
Bo Kyeong KANG
Author Information
- Publication Type:Original Article
- From:Gut and Liver 2021;15(1):109-116
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background/Aims:To date, studies on various noninvasive techniques have been suggested to evaluate the degree of liver fibrosis. We aimed to investigate the diagnostic performance of se-rum asialo α1-acid glycoprotein (AsAGP) in the diagnosis of liver cirrhosis compared with chronic hepatitis for clinically useful result.
Methods:We conducted a case-control study of 96 patients with chronic liver disease. Chronic hepatitis was defined as the presence of chronic liver disease on ultrasonography, with a liver stiffness of less than 5.0 kPa as shown on magnetic resonance elastography (MRE). Liver cirrho-sis was defined as liver stiffness of more than 5.0 kPa on MRE. The serum AsAGP concentration was compared between the two groups.
Results:Serum AsAGP levels were significantly higher in patients with cirrhosis than in those with chronic hepatitis (1.83 μg/mL vs 1.42 μg/mL, p<0.001). Additionally, when comparing pa-tients in each cirrhotic group (Child-Pugh grades A, B, and C) to those with chronic hepatitis, AsAGP levels were significantly higher in all the cirrhotic groups (p<0.05, p<0.01, p<0.001, respectively). The sensitivity and specificity of AsAGP for detecting cirrhosis were 79.2% and 64.6%, respectively, and the area under the curve value was 0.733. The best diagnostic cutoff to predict cirrhosis was 1.4 μg/mL. AsAGP and bilirubin were found to be independent risk factors for the prediction of cirrhosis in the logistic regression analysis.
Conclusions:Serum AsAGP showed an acceptable diagnostic performance in predicting liver cirrhosis.
