Antaroide, a Novel Natural Nine-Membered Macrolide, Inhibits Melanin Biosynthesis in B16F10 Murine Melanoma Cells
10.4062/biomolther.2020.064
- Author:
Min-Ji RYU
1
;
Eun-Ki BAEK
;
Soyeon KIM
;
Chi Nam SEONG
;
Inho YANG
;
Kyung-Min LIM
;
Sang-Jip NAM
Author Information
1. Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea
- Publication Type:Original Article
- From:Biomolecules & Therapeutics
2021;29(1):98-103
- CountryRepublic of Korea
- Language:English
-
Abstract:
AbstractThe demand for natural substances with anti-melanogenic activity is increasing due to the recent interest in skin whitening. Intensive investigation on the culture broth of Streptomyces sp. SCO-736, a marine bacterium from the Antarctica coast, has led to the isolation of a new natural product named antaroide (1). The chemical structure was established through the interpretation of MS, UV, and NMR spectroscopic data. Antaroide is a nine-membered macrolide with lactone and lactam moieties. To investigate its applicability in skin whitening cosmetics, its anti-melanogenic activity in B16F10 murine melanoma cells was examined. As a result, antaroide displayed strong inhibitory activities against melanin synthesis and also attenuated the dendrite formation induced by the α-melanocyte stimulating hormone (α-MSH). Antaroide suppressed the mRNA expression of the melanogenic enzymes such as tyrosinase, TRP-1 and TRP-2. This suggests that it may serve as a transcriptional regulator of melanogenesis. Collectively, the discovery of this novel natural nine-membered macrolide and its anti-melanogenic activity could give new insights for the development of skin whitening agents.
