Effectiveness of 5-day Post-exposure Prophylactic Oseltamivir and Its Effect on Hospital Management

Takayuki Mokubo; Mayuko Hamada; Yasutomo Ishii; Aya Miyamoto; Koichiro Mukai; Yuki Tokutake; Koji Ueda; Hiroshi Matsuoka

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Effectiveness of 5-day Post-exposure Prophylactic Oseltamivir and Its Effect on Hospital Management

VernacularTitle:曝露後予防におけるオセルタミビル5日間投与の有効性評価と病院経営への影響
Author: Takayuki MOKUBO ¹ ; Mayuko HAMADA ¹ ; Yasutomo ISHII ² ; Aya MIYAMOTO ¹ ; Koichiro MUKAI ³ ; Yuki TOKUTAKE ¹ ; Koji UEDA ⁴ ; Hiroshi MATSUOKA ⁵
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1. Dept. of Pharmacy, Yashima General Hospital
2. Dept. of Central Clinical Laboratory, Yashima General Hospital
3. Dept. of Medical Information Division, Yashima General Hospital
4. Dept. of Surgery, Yashima General Hospital
5. Dept. of Internal, Yashima General Hospital
From:Journal of the Japanese Association of Rural Medicine 2021;69(5):489-493
CountryJapan
Language:Japanese
Abstract: Prophylaxis is sometimes offered to inpatients who share a room with, or individuals who have been in close contact with, patients who have contracted influenza. In our hospital, 5-day prophylactic oseltamivir has been used as a standard procedure. Here, we investigated the effectiveness of this post-exposure prophylaxis for inpatients and healthcare professionals, as well as its effect on hospital management. The study period was 5 years from fiscal year 2013 to fiscal year 2017, and the effectiveness outcome was the secondary infection rate. Medication costs for this prophylaxis were compared with those for oseltamivir used according to the package insert. The secondary infection rates were 3.0% and 0.5% in 133 inpatients and 434 healthcare professionals who had received post-exposure oseltamivir, respectively. The medication costs were reduced by 50% compared with the estimated costs for 10-day oseltamivir administration. The effectiveness of 5-day prophylactic oseltamivir was similar to or higher than that reported previously, indicating that this prophylaxis was effective. Moreover, 5-day post-exposure prophylactic oseltamivir is expected to reduce the prolongation of hospital stay and influenza outbreaks and thus contribute to hospital management.