How much platelet-rich plasma can be soak-loaded onto beta-tricalcium phosphate? A comparison with or without a unidirectional porous structure

Norihito Arai; Tomokazu Yoshioka; Hisashi Sugaya; Akihiro Kanamori; Masashi Yamazaki

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How much platelet-rich plasma can be soak-loaded onto beta-tricalcium phosphate? A comparison with or without a unidirectional porous structure

VernacularTitle:How much platelet-rich plasma can be soak-loaded onto beta-tricalcium phosphate? A comparison with or without a unidirectional porous structure
Author: Norihito ARAI ¹ ; Tomokazu YOSHIOKA ¹ ; Hisashi SUGAYA ² ; Akihiro KANAMORI ¹ ; Masashi YAMAZAKI ¹
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1. Department of Orthopedic Surgery, Faculty of Medicine, University of Tsukuba, Japan
2. Division of Regenerative Medicine for Musculoskeletal System, Faculty of Medicine, University of Tsukuba, Japan
Keywords: β-tricalcium phosphate; platelet-rich plasma; loaded volume; unidirectional porous; artificial bone
From:Journal of Rural Medicine 2021;16(1):14-21
CountryJapan
Language:English
Abstract: Objective: This study aimed to examine differences in platelet-rich plasma (PRP) soak-loaded volumes of β-tricalcium phosphate (β-TCP) with or without a unidirectional porous structure.Materials and Methods: Leukocyte-rich PRP was extracted from 15 healthy volunteers by centrifugation. Two types of artificial bones were soaked for either ten seconds or ten minutes. The volume ratios of PRP soak-loaded onto the artificial bone and soaked area ratios were evaluated. Statistical analyses were performed using the Tukey-Kramer HSD test and the Games-Howell method. A P-value of <0.05 was considered statistically significant.Results: Regardless of the soaking time, the PRP soak-loaded volume ratio and soaked area ratio were significantly higher in the unidirectional porous β-TCP (UDPTCP) group than in the spherical porous β-TCP (SPTCP) group.Conclusion: PRP can be soak-loaded faster and in larger amounts onto UDPTCP compared to SPTCP. Understanding the basic biology of β-TCP soak-loaded with PRP can help develop more novel and effective β-TCP treatments for orthopedic surgery.