The Correlation between Apoptotic Index and Gleason Grade in Prostate Carcinoma.
- Author:
Youn Jun SONG
1
;
Dae Yul YANG
;
Eun Sook NAM
Author Information
1. Department of Urology, Hallym University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Apoptosis;
Prostate cancer
- MeSH:
Apoptosis;
Biopsy, Needle;
Cell Death;
Humans;
Prostate*;
Prostatectomy;
Prostatic Neoplasms;
Transurethral Resection of Prostate
- From:Korean Journal of Urology
1998;39(6):589-592
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Apoptosis is a process of natural cell death that can occur under both normal and neoplastic conditions and increased apoptosis in neoplastic conditions is a feature of the increasing malignant potential. We investigated the possible relationship between the apoptotic index(AI) and Gleason grade, T stage of prostatic carcinoma. MATERIALS AND METHODS: A total of 31 patients with untreated prostatic carcinoma diagnosed by TURP, transrectal needle biopsy and radical prostatectomy was evaluated. We used in situ end labeling method for apoptotic staining. AI was compared with Gleason grade and T stage. RESULTS: The values of mean AI according to Gleason grade were grade I, 1.3+/- 0.13, II, 1.38+/-0.11, III, 1.92+/-0.20, IV, 2.0+/-0.20, V, 2.01 +/-0.28. A positive correlation was noted between apoptotic index and Gleason grade, but not between apoptotic index and T stage. CONCLUSIONS: We found a positive correlation between AI and Gleason grade and the possibility that AI may serve as an important morphological marker to predict the behavior of prostatic carcinoma.
