The Effect of Intraurethral Instillation of PGE1 Solution in Patients with Erectile Dysfunction.
- Author:
Seong Gon BAE
1
;
Gyeong Min KANG
;
Tae Gyun KWON
;
Sung Kwang CHUNG
;
Yun Kyu PARK
Author Information
1. Department of Urology, Kyungpook National University, College of Medicine, Taegu, Korea.
- Publication Type:Original Article
- Keywords:
Intraurethral instillation;
Prostaglandin El;
Erectile dysfunction
- MeSH:
Alprostadil*;
Erectile Dysfunction*;
Humans;
Male;
Penile Erection
- From:Korean Journal of Urology
1998;39(6):601-604
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Intracavernosal self injection therapy is now being widely used to treat patients with erectile dysfunction. However, there is a large number of patients who give up the self injection program due to the fear of injection. Therefore, less invasive route of drug administration is highly recommended. We investigated the efficacy of intraurethral instillation of Prostaglandin El (PGE1 ) solution in the patients who showed full erection with intracavernosal injection of PGE1. MATERIALS AND METHODS: Twenty-nine impotent patients who showed full erection with intracavernosal injection of PGE1 were included in this study. We estimated the grades and durations of the penile erection after intraurethral instillation of PGE1 RESULTS: Sixteen out of 29 patients(55.2%) showed full erection with intraurethral instillation. Two patients(6.9%) showed urethral pain which disappeared within 24 hours. But there was no systemic side effect CONCLUSIONS: Intraurethral instillation of PGE1 appears to be safe, well tolerated, and less invasive treatment modality Thus it can be selected as an alternative treatment of impotence in selected cases.
