Role of anion exchanger 2 in the pathogenesis of primary biliary cholangitis
DOI:10.3969/j.issn.1001-5256.2021.03.044
- VernacularTitle:阴离子交换蛋白2与原发性胆汁性胆管炎发病机制的关系
- Author:
Xi CHU
1
;
Lianjun XING
Author Information
1. Second Department of Spleen and Stomach, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200000, China
- Publication Type:Research Article
- Keywords:
Primary Biliary Cholangitis;
Antiporters;
Pathologic Processes
- From:
Journal of Clinical Hepatology
2021;37(3):718-720
- CountryChina
- Language:Chinese
-
Abstract:
The etiology and pathogenesis of primary biliary cholangitis (PBC) remain unclear at present, and it is believed that the change in bile duct microenvironment and autoimmune response are the main factors for the onset of this disease. Anion exchanger 2 (AE2) is an HCO3-/Cl- exchange protein located on the membrane of epithelial cells and has been taken seriously by scholars since studies have shown that it can induce and aggravate PBC. This article summarizes the role of AE2 in bile duct microenvironment and autoimmune response from the aspects of AE2 and related regulatory mechanisms and further analyzes the pathogenesis of PBC, so as to find new therapies and diagnostic and prognostic indicators for PBC by exploring the regulatory mechanism of AE2 in PBC.
