Role of HCO3- umbrella in the pathogenesis of primary biliary cholangitis
DOI:10.3969/j.issn.1001-5256.2021.03.043
- VernacularTitle:碳酸氢根伞在原发性胆汁性胆管炎发病机制中的作用
- Author:
Yinghao CHANG
1
;
Dan JING
;
Wenjiao XU
;
Xiaolei ZHOU
;
Xiaoping WANG
;
Shanhong TANG
Author Information
1. Department of Gastroenterology, The General Hospital of Western Theater Command, Chengdu 610083, China
- Publication Type:Research Article
- Keywords:
Liver Cirrhosis, Biliary;
Bicarbonates;
Bile Acids and Salts;
Biliary Epithelial Cells
- From:
Journal of Clinical Hepatology
2021;37(3):714-717
- CountryChina
- Language:Chinese
-
Abstract:
Primary biliary cholangitis (PBC) is an autoimmune disease. Although PBC has the features of autoimmune disease, it has poor response to immunosuppressants and good response to the drugs participating in bile acid metabolism, such as ursodeoxycholic acid. Studies have shown that the bicarbonate secretion of biliary epithelial cells is impaired in PBC patients, and bile acid not blocked by HCO3- umbrella enters biliary epithelial cells and mediates their damage and apoptosis, leading to the expression of autoantibodies in apoptotic cells and immunologic injury. In order to explore the role of HCO3- umbrella secreted by biliary epithelial cells in the pathogenesis of PBC, this article briefly introduces the physiological function and production mechanism of HCO3- umbrella and the influencing factors for HCO3- secretion, and it is pointed out that reduced HCO3- secretion may be a key link in the pathogenesis of PBC and a potential therapeutic target.
