Role of long non-coding RNA MALAT1 in the development and progression of hepatocellular carcinoma
DOI:10.3969/j.issn.1001-5256.2021.03.041
- VernacularTitle:长链非编码RNA MALAT1在肝细胞癌发生发展中的作用
- Author:
Yongkang SUN
1
;
Xuebo YAN
;
Zemin ZHU
;
Dingcheng SHEN
;
Zhiqin XIE
;
Zhijian ZHAO
;
Caixi TANG
Author Information
1. Department of Hepatobiliary and Pancreatosplenic Surgery, Affiliated Zhuzhou Hospital, Xiangya Medical College, Central South University, Zhuzhou, Hunan 412007, China
- Publication Type:Research Article
- Keywords:
Carcinoma, Hepatocellular;
RNA, Long Noncoding;
Metastasis-Associated Lung Adenocarcinoma Transcript 1
- From:
Journal of Clinical Hepatology
2021;37(3):704-708
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma (HCC) has the features of high incidence rate, low survival rate, poor treatment outcome, and complex pathogenesis. In recent years, many studies have shown that long non-coding RNA (lncRNA) MALAT1 is upregulated in HCC and can promote the proliferation, invasion, and metastasis of HCC cells, and it can also guide the diagnosis, prognostic evaluation, and treatment of HCC in clinical practice. This article reviews the current status of research on lncRNA MALAT1 in HCC and discusses its expression pattern, mechanism of action, and clinical significance in predicting and monitoring the progression of HCC, so as to gain a deep understanding of the role of lncRNA MALAT1 in the progression of HCC. It is pointed out that lncRNA MALAT1 is expected to become a potential biomarker for the diagnosis and prognostic evaluation of HCC and may be used as a therapeutic target in clinical practice.
